三、主要科研工作

主要研究领域为癌症治疗和肿瘤免疫学机制的研究。熟悉癌症相关细胞信号通路的作用机制和研究手段、精通细胞培养和动物模型以及抗肿瘤药物作用机制研究。研究方向主要包括以小鼠和人类为研究对象，基于多种小鼠肿瘤模型进行联合治疗的抗癌效率和免疫学机制的深入研究等。参与多项国家自然科学基金项目，并参加Oncode学术会议， NWO Chain化学会议，世界TGF-beta研讨会等多个国际学术会议。

四、科研成果（著作、专利、论文

Hao, Y, Ma S, Gu, Z, et al., Combination of photodynamic therapy and stimulator of interferon genes (STING) agonist inhibits colorectal tumor growth and recurrence. Cancer Commun (Lond). 2023;43(4):513-518.
Gu Z, Da Silva CG, Hao Y, et al. Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer. J Control Release. 2023
Gu Z, Hao Y, Schomann T, et al. Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation. J Control Release. 2023;357:531-544.
Hao, Y, Chung CK, Gu, Z, et al. Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment. Mol Biomed. 2022;3(1):26
Hao, Y, Gu, Z, Yu, Z, et al., Photodynamic Therapy in Combination with the Hepatitis B Core virus-like particles (HBc VLPs) to Prime Anticancer Immunity for Colorectal Cancer Treatment. Cancers 2022;14(11):2724.
Hao Y, Chung CK, Yu Z, et al. Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy. Pharmaceutics. 2022;14(1):120.
Gu Z, Da Silva CG, Hao Y, et al., Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer. J Control Release. 2022; S0168-3659(22)00804-5
Yu Z, He Y, Schomann T, Wu K, Hao Y, et al., Rare-Earth-Metal (Nd3+, Ce3+ and Gd3+)-Doped CaF2: Nanoparticles for Multimodal Imaging in Biomedical Applications. Pharmaceutics. 2022; 14(12):2796.
Yu Z, He Y, Schomann T, Wu K, Hao Y, et al. Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles. Pharmaceutics. 2022;14(4):840.
Cai M, Zeng Y, Liu M, You L, Huang H, Hao Y, et al. Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy. Pharmaceutics. 2021 Nov 17;13(11):1945.
Dong X, Zeng Y, Zhang Z, Fu J, You L, He Y, Hao Y, et al. Hypericin-mediated photodynamic therapy for the treatment of cancer: a review. J Pharm Pharmacol. 2021 Mar 8;73(4):425-436.
Hao J, Li C, Lin C, Hao, Y., et al. Targeted point mutations of the m6A modification in miR675 using RNA-guided base editing induce cell apoptosis. Biosci Rep. 2020;40(5): BSR20192933.
Hao, Y., Baker, D., & Ten Dijke, P. (2019). TGF-beta-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. Int J Mol Sci, 20(11).
Zhong X*, Liu D*, Hao Y*, et al. The expression of TET3 regulated cell proliferation in HepG2 cells. Gene. 2019; 698:113-119.
Shen Z, Ma Y, Ji Z., Hao, Y., et al. Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway. Lipids Health Dis. 2018;17(1):26.
Hao Y, Wang G, Lin C, et al. Valproic Acid Induces Decreased Expression of H19 Promoting Cell Apoptosis in A549 Cells. DNA Cell Biol. 2017;36(6):428-435.
Wang D*, Wang G*, Yang H*, et al. DNA methylation modulates H19 and IGF2 expression in porcine female eye. Genet Mol Biol. 2017;40(1):153-159.
Wang, D., Liu, Z., Yao, H., Hao, Y., et al. Disruption of NNAT, NAP1L5 and MKRN3 DNA methylation and transcription in rabbit parthenogenetic fetuses. Gene. 2017; 626: 158-162.
Ji ZH, Ren WZ, Gao W, Hao, Y., et al. Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms on Listeria monocytogenes infection. Oncotarget. 2017;8(63):106222-106232